Cancer Therapy: Preclinical A Targeted RNAi Screen of the Breast Cancer Genome IdentifiesKIF14 and TLN1 asGenes ThatModulateDocetaxel Chemosensitivity in Triple-Negative Breast Cancer
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چکیده
Purpose: To identify biomarkers within the breast cancer genome that may predict chemosensitivity in
منابع مشابه
A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer.
PURPOSE To identify biomarkers within the breast cancer genome that may predict chemosensitivity in breast cancer. EXPERIMENTAL DESIGN We conducted an RNA interference (RNAi) screen within the breast cancer genome for genes whose loss-of-function enhanced docetaxel chemosensitivity in an estrogen receptor-negative, progesterone receptor-negative, and Her2-negative (ER-, PR-, and Her2-, respec...
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Background: Triple-negative breast cancer (TNBC) is treated with highly aggressive non-targeted chemotherapies. Safer and more effective therapeutic approaches than those currently in use are needed. Natural pomegranate peel extract (PPE) has recently been found to inhibit breast cancer progression; however, its mechanisms of action remain unclear. We hypothesized that transcriptional chan...
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تاریخ انتشار 2013